Article
Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.
Cancer - 15 Jan 2016
Churpek Jane E, Marquez Rafael, Neistadt Barbara, Claussen Kimberly, Lee Ming K, Churpek Matthew M, Huo Dezheng, Weiner Howard, Bannerjee Mekhala, Godley Lucy A, Le Beau Michelle M, Pritchard Colin C, Walsh Tom, King Mary-Claire, Olopade Olufunmilayo I, Larson Richard A
Abstract excerpt
BACKGROUND: Risk factors for the development of therapy-related leukemia (TRL), an often lethal late complication of cytotoxic therapy, remain poorly understood and may differ for survivors of different malignancies. Survivors of breast cancer (BC) now account for the majority of TRL cases, making the study of TRL risk factors in this population a priority. METHODS: Subjects with TRL after cytotoxic therapy for a...
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