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Article

Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Feb 2016

Wahlberg Karin, Kippler Maria, Alhamdow Ayman, Rahman Syed Moshfiqur, Smith Donald R, Vahter Marie, Lucchini Roberto G, Broberg Karin

Abstract excerpt

Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. We evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes an Mn transporter, influence blood Mn concentrations and neurological function. We measured blood Mn concentrations by...

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PMID: 26628504
DOI: 10.1093/toxsci/kfv252
PMCID: PMC4725612

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