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Article

Endoplasmic reticulum stress intolerance in EIF2B3 mutant oligodendrocytes is modulated by depressed autophagy.

Brain & development - 1 May 2016

Chen Na, Dai Lifang, Jiang Yuwu, Wang Jingmin, Hao Hongjun, Ren Yali, Leng Xuerong, Zang Lili, Wu Ye

Abstract excerpt

OBJECTIVE: Eukaryotic translation initiation factor 2B (eIF2B) is an essential factor for the initiation of protein synthesis. Mutations in eIF2B encoded by EIF2B1-5 cause a lethal leukoencephalopathy--vanishing white matter disease (VWM). Previous studies have suggested that an improper activated unfolded protein response (UPR) after endoplasmic reticulum stress (ERS) contributed to the pathogenesis of the...

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PMID: 26625702
DOI: 10.1016/j.braindev.2015.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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