Article
A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer.
PLoS neglected tropical diseases - 1 Nov 2015
Eddyani Miriam, Vandelannoote Koen, Meehan Conor J, Bhuju Sabin, Porter Jessica L, Aguiar Julia, Seemann Torsten, Jarek Michael, Singh Mahavir, Portaels Françoise, Stinear Timothy P, de Jong Bouke C
Abstract excerpt
BACKGROUND: Increased availability of Next Generation Sequencing (NGS) techniques allows, for the first time, to distinguish relapses from reinfections in patients with multiple Buruli ulcer (BU) episodes. METHODOLOGY: We compared the number and location of single nucleotide polymorphisms (SNPs) identified by genomic screening between four pairs of Mycobacterium ulcerans isolates collected at the time of first...
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