Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample.

doi:10.1016/j.euroneuro.2015.11.007

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Article

Replication of the association between CHRNA4 rs1044396 and harm avoidance in a large population-based sample.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2016

Bey Katharina, Lennertz Leonhard, Markett Sebastian, Petrovsky Nadine, Gallinat Jürgen, Gründer Gerhard, Spreckelmeyer Katja N, Wienker Thomas F, Mobascher Arian, Dahmen Norbert, Thuerauf Norbert, Kornhuber Johannes, Kiefer Falk, Toliat Mohammad R, Nürnberg Peter, Winterer Georg, Wagner Michael

Abstract excerpt

Harm avoidance is a personality trait characterized by excessive worrying and fear of uncertainty, which has repeatedly been related to anxiety disorders. Converging lines of research in rodents and humans point towards an involvement of the nicotinic cholinergic system in the modulation of anxiety. Most notably, the rs1044396 polymorphism in the CHRNA4 gene, which codes for the α4 subunit of the nicotinic...

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PMID: 26612384
DOI: 10.1016/j.euroneuro.2015.11.007

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CHRNA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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