Enhancing effect of phenotype mutational robustness on adaptation in Escherichia coli.

Abstract excerpt

Theoretical and computational studies predict a positive role for widespread phenotype resistance to genetic mutation, or "phenotype mutational robustness," in enhancing adaptation to novel environments through the accumulation of cryptic genetic variation. However, this has not been verified through experimental evolution in biological systems at the level of whole organisms. In a short-term evolution experiment...

Topics

• Adaptation, Physiological
• Culture Media
• Directed Molecular Evolution
• Environment
• Escherichia coli
• Genetic Variation
• Genotype
• Glycerol
• Lactic Acid
• Mutation
• Phenotype