Article
Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms.
European journal of cancer (Oxford, England : 1990) - 1 Dec 2015
Johnson Douglas B, Menzies Alexander M, Zimmer Lisa, Eroglu Zeynep, Ye Fei, Zhao Shilin, Rizos Helen, Sucker Antje, Scolyer Richard A, Gutzmer Ralf, Gogas Helen, Kefford Richard F, Thompson John F, Becker Jürgen C, Berking Carola, Egberts Friederike, Loquai Carmen, Goldinger Simone M, Pupo Gulietta M, Hugo Willy, Kong Xiangju, Garraway Levi A, Sosman Jeffrey A, Ribas Antoni, Lo Roger S, Long Georgina V, Schadendorf Dirk
Abstract excerpt
BACKGROUND: Acquired resistance to BRAF inhibitors (BRAFi) is a near-universal phenomenon caused by numerous genetic and non-genetic alterations. In this study, we evaluated the spectrum, onset, pattern of progression, and subsequent clinical outcomes associated with specific mechanisms of resistance. METHODS: We compiled clinical and genetic data from 100 patients with 132 tissue samples obtained at progression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.