Article
Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes.
Nature communications - 26 Nov 2015
Xu Feng, Wu Ling-Yun, Chang Chun-Kang, He Qi, Zhang Zheng, Liu Li, Shi Wen-Hui, Guo Juan, Zhu Yang, Zhao You-Shan, Gu Shu-Cheng, Fei Cheng-Ming, Wu Dong, Zhou Li-Yu, Su Ji-Ying, Song Lu-Xi, Xiao Chao, Li Xiao
Abstract excerpt
The progressive mechanism underlying myelodysplastic syndrome remains unknown. Here we identify ROBO1 and ROBO2 as novel progression-related somatic mutations using whole-exome and targeted sequencing in 6 of 16 (37.5%) paired MDS patients with disease progression. Further deep sequencing detects 20 (10.4%) patients with ROBO mutations in a cohort of 193 MDS patients. In addition, copy number loss and loss of...
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