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MicroRNA-1182 and let-7a exert synergistic inhibition on invasion, migration and autophagy of cholangiocarcinoma cells through down-regulation of NUAK1

9 Mar 2021

Abstract excerpt

BACKGROUND: Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore the potential effects of miR-1182 and let-7a on CCA development. METHODS: Bioinformatics analysis was conducted to screen differentially expressed genes in CCA, Western blot analysis detected NUAK1...

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PMID: 33750398
DOI: 10.1186/s12935-021-01797-z

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