Article
Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza.
The Journal of infectious diseases - 1 Apr 2016
Schulert Grant S, Zhang Mingce, Fall Ndate, Husami Ammar, Kissell Diane, Hanosh Andrew, Zhang Kejian, Davis Kristina, Jentzen Jeffrey M, Napolitano Lena, Siddiqui Javed, Smith Lauren B, Harms Paul W, Grom Alexei A, Cron Randy Q
Abstract excerpt
BACKGROUND: Severe H1N1 influenza can be lethal in otherwise healthy individuals and can have features of reactive hemophagocytic lymphohistiocytosis (HLH). HLH is associated with mutations in lymphocyte cytolytic pathway genes, which have not been previously explored in H1N1 influenza. METHODS: Sixteen cases of fatal influenza A(H1N1) infection, 81% with histopathologic hemophagocytosis, were identified and...
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