Article
Inexpensive Computation of the Inverse of the Genomic Relationship Matrix in Populations with Small Effective Population Size.
Genetics - 1 Feb 2016
Misztal Ignacy
Abstract excerpt
Many computations with SNP data including genomic evaluation, parameter estimation, and genome-wide association studies use an inverse of the genomic relationship matrix. The cost of a regular inversion is cubic and is prohibitively expensive for large matrices. Recent studies in cattle demonstrated that the inverse can be computed in almost linear time by recursion on any subset of ∼10,000 individuals. The...
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