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Marker effect p-values for single-step GWAS with the algorithm for proven and young in large genotyped populations.

Genetics, selection, evolution : GSE - 22 Aug 2024

Leite Natália Galoro, Bermann Matias, Tsuruta Shogo, Misztal Ignacy, Lourenco Daniela

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphism (SNP) effects can be backsolved from ssGBLUP genomic estimated breeding values (GEBV) and used for genome-wide association studies (ssGWAS). However, obtaining p-values for those SNP effects relies on the inversion of dense matrices, which poses computational limitations in large genotyped populations. In this study, we present a method to approximate SNP p-values for...

Topics

Polymorphism, Single Nucleotide
Animals
Algorithms
Genome-Wide Association Study
Genotype
Models, Genetic
Breeding
Genetic Markers

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39174924
DOI: 10.1186/s12711-024-00925-3
PMCID: PMC11340074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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