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Article

Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver.

Molecular biology and evolution - 1 Mar 2016

Engelken Johannes, Espadas Guadalupe, Mancuso Francesco M, Bonet Nuria, Scherr Anna-Lena, Jímenez-Álvarez Victoria, Codina-Solà Marta, Medina-Stacey Daniel, Spataro Nino, Stoneking Mark, Calafell Francesc, Sabidó Eduard, Bosch Elena

Abstract excerpt

Essential trace elements possess vital functions at molecular, cellular, and physiological levels in health and disease, and they are tightly regulated in the human body. In order to assess variability and potential adaptive evolution of trace element homeostasis, we quantified 18 trace elements in 150 liver samples, together with the expression levels of 90 genes and abundances of 40 proteins involved in their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26582562
DOI: 10.1093/molbev/msv267
PMCID: PMC4760079

Genes

HFE
FST
GPX1
GPX2
GPX3
SELENBP1

Variants

rs10133290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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