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Article

Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates.

American journal of human genetics - 3 Dec 2015

Palamara Pier Francesco, Francioli Laurent C, Wilton Peter R, Genovese Giulio, Gusev Alexander, Finucane Hilary K, Sankararaman Sriram, Sunyaev Shamil R, de Bakker Paul I W, Wakeley John, Pe'er Itsik, Price Alkes L

Abstract excerpt

The rate at which human genomes mutate is a central biological parameter that has many implications for our ability to understand demographic and evolutionary phenomena. We present a method for inferring mutation and gene-conversion rates by using the number of sequence differences observed in identical-by-descent (IBD) segments together with a reconstructed model of recent population-size history. This approach...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26581902
DOI: 10.1016/j.ajhg.2015.10.006
PMCID: PMC4678427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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