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Article

Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer.

Scientific reports - 19 Nov 2015

Gupta Shilpi, Kumar Prabhat, Kaur Harsimrut, Sharma Nishi, Saluja Daman, Bharti Alok C, Das Bhudev C

Abstract excerpt

Tongue squamous cell carcinoma (TSCC) is most aggressive head and neck cancer often associated with HR-HPV infection. The role of AP-1 which is an essential regulator of HPV oncogene expression and tumorigenesis is not reported in tongue cancer. One hundred tongue tissue biopsies comprising precancer, cancer and adjacent controls including two tongue cancer cell lines were employed to study the role of HPV...

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Source

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Identifiers

PMID: 26581505
DOI: 10.1038/srep16811
PMCID: PMC4652185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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