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Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo

19 Nov 2015

Abstract excerpt

MicroRNAs (miRNAs) can impact viral infections by binding to sequences with partial complementarity on viral RNA transcripts, usually resulting in the repression of virus replication. In the present study, we identified a potential binding site for miR-130 in the 5' untranslated region (bps 155-162) of the porcine reproductive and respiratory syndrome virus (PRRSV) genome. We found that the delivery of multiple...

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PMID: 26581169
DOI: 10.1038/srep17010

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