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Article

Utilizing host endogenous microRNAs to negatively regulate the replication of porcine reproductive and respiratory syndrome virus in MARC-145 cells.

PloS one - 1 Jan 2018

Li Liwei, Gao Fei, Zheng Hao, Jiang Yifeng, Tong Wu, Zhou Yanjun, Tong Guangzhi

Abstract excerpt

MicroRNAs (miRNAs) contribute to gene regulation at the post-transcriptional level and are capable of mRNA silencing by binding to target sites exhibiting high degrees of complementarity. Therefore, cloning host miRNA-recognition sequences into the genome of RNA viruses represents a rational strategy for manipulating viral replication. Here, we performed deep sequencing to obtain small-RNA (sRNA)-expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29969475
DOI: 10.1371/journal.pone.0200029
PMCID: PMC6029797

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