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MicroRNA-30c targets the interferon–alpha/beta receptor beta chain to promote type 2 PRRSV infection

1 Nov 2018

Abstract excerpt

Porcine reproductive and respiratory syndrome (PRRS) is one of the most important diseases in pigs. MicroRNAs (miRNAs) have emerged as an important regulator of virus-host cell interactions and miR-30c has been found to facilitate PRRSV replication. Here, we found that the interferon-alpha/beta receptor beta chain (IFNAR2) was down-regulated, while miR-30c was up-regulated during HV (a highly pathogenic type 2...

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PMID: 30382935
DOI: 10.1099/jgv.0.001166

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