Article
Integrated genomics approach to identify biologically relevant alterations in fewer samples.
BMC genomics - 14 Nov 2015
Chandrani Pratik, Upadhyay Pawan, Iyer Prajish, Tanna Mayur, Shetty Madhur, Raghuram Gorantala Venkata, Oak Ninad, Singh Ankita, Chaubal Rohan, Ramteke Manoj, Gupta Sudeep, Dutt Amit
Abstract excerpt
BACKGROUND: Several statistical tools have been developed to identify genes mutated at rates significantly higher than background, indicative of positive selection, involving large sample cohort studies. However, studies involving smaller sample sizes are inherently restrictive due to their limited statistical power to identify low frequency genetic variations. RESULTS: We performed an integrated characterization...
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