Article
Structural impact of proline mutations in the loop region of an ancestral membrane protein.
Biopolymers - 1 Jan 2016
Nadeau Vincent G, Deber Charles M
Abstract excerpt
The sodium ion-translocating F0 F1 ATP synthase from the bacterium Ilyobacter tartaricus contains a highly stable rotor ring composed of 11 c subunits. The synthase subunit c-in effect an 89-residue peptide that folds into a helical hairpin consisting of two membrane-spanning helices and a cytoplasmic loop-was probed for the structural impact of a series of substitutions with the β-turn-inducing proline-glycine...
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