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Article

Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases.

Endocrine journal - 1 Jan 2016

Yoshie Namiki, Watanabe Mikio, Inoue Naoya, Kawaguchi Hayaka, Hidaka Yoh, Iwatani Yoshinori

Abstract excerpt

The prognosis of autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's disease (HD), varies among patients. Inducible co-stimulator (ICOS) (CD278) and co-stimulator ligand (ICOSL) (CD275) are important costimulatory molecules. Their interactions play important roles in immune regulation and the pathogenesis of autoimmune diseases through tuning T cell activation, differentiation and...

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Source

Identifiers

PMID: 26560438
DOI: 10.1507/endocrj.EJ15-0435

Genes

ICOS

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