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Methane Trajectory Phenotypes on Glucose Breath Testing Are Associated With Slow Colonic Transit: A Group-Based Trajectory Modeling Analysis.

Neurogastroenterology and motility - 1 Jul 2026

Sirimongkolkasem Jarongkorn, Valencia Briana, Becker Laren, Spencer Sean, Sonu Irene, Nguyen Linda, Neshatian Leila

Abstract excerpt

BACKGROUND: Intestinal methanogen overgrowth (IMO) is defined by a single binary threshold of CH4 ≥ 10 ppm and is associated with slow transit constipation. We aimed to identify distinct breath methane trajectory phenotypes in patients with constipation and test their association with slow colonic transit. METHODS: We retrospectively analyzed 188 adults with constipation who underwent glucose breath testing and...

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Identifiers

PMID: 42509595
DOI: 10.1111/nmo.70409
PMCID: PMC13408215

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