Article
A network-based method to evaluate quality of reproducibility of differential expression in cancer genomics studies.
Oncotarget - 29 Dec 2015
Li Robin, Lin Xiao, Geng Haijiang, Li Zhihui, Li Jiabing, Lu Tao, Yan Fangrong
Abstract excerpt
BACKGROUND: Personalized cancer treatments depend on the determination of a patient's genetic status according to known genetic profiles for which targeted treatments exist. Such genetic profiles must be scientifically validated before they is applied to general patient population. Reproducibility of findings that support such genetic profiles is a fundamental challenge in validation studies. The percentage of...
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