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Article

Identifying tightly regulated and variably expressed networks by Differential Rank Conservation (DIRAC).

PLoS computational biology - 27 May 2010

Eddy James A, Hood Leroy, Price Nathan D, Geman Donald

Abstract excerpt

A powerful way to separate signal from noise in biology is to convert the molecular data from individual genes or proteins into an analysis of comparative biological network behaviors. One of the limitations of previous network analyses is that they do not take into account the combinatorial nature of gene interactions within the network. We report here a new technique, Differential Rank Conservation (DIRAC),...

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Identifiers

PMID: 20523739
DOI: 10.1371/journal.pcbi.1000792
PMCID: PMC2877722

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