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Article

Mutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation.

Psychiatric genetics - 1 Apr 2016

Carroll Liam S, Woolf Rebecca, Ibrahim Yousef, Williams Hywel J, Dwyer Sarah, Walters James, Kirov George, O'Donovan Michael C, Owen Michael J

Abstract excerpt

OBJECTIVES: There is a growing body of evidence suggesting a shared genetic susceptibility between many neuropsychiatric disorders, including schizophrenia, autism, intellectual disability (ID) and epilepsy. The sodium channel, voltage-gated type II α subunit gene SCN2A has been shown to exhibit loss-of-function (LoF) mutations in individuals with seizure disorders, ID, autism and schizophrenia. The role of LoF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26555645
DOI: 10.1097/YPG.0000000000000110
PMCID: PMC4756433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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