Article
Stimulation with lysates of Aspergillus terreus, Candida krusei and Rhizopus oryzae maximizes cross-reactivity of anti-fungal T cells.
Cytotherapy - 1 Jan 2016
Deo Shivashni S, Virassamy Balaji, Halliday Catriona, Clancy Leighton, Chen Sharon, Meyer Wieland, Sorrell Tania C, Gottlieb David J
Abstract excerpt
BACKGROUND AIMS: Invasive fungal diseases caused by filamentous fungi and yeasts are significant causes of morbidity and mortality in immunosuppressed hematology patients. We previously published a method to expand Aspergillus fumigatus-specific T cells for clinical cell therapy. In the present study, we investigated expansion of T cells specific for other fungal pathogens and creation of a broadly reactive...
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