Article
The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65.
Antiviral research - 1 Dec 2015
Hutterer Corina, Niemann Ina, Milbradt Jens, Fröhlich Tony, Reiter Christoph, Kadioglu Onat, Bahsi Hanife, Zeitträger Isabel, Wagner Sabrina, Einsiedel Jürgen, Gmeiner Peter, Vogel Nico, Wandinger Sebastian, Godl Klaus, Stamminger Thomas, Efferth Thomas, Tsogoeva Svetlana B, Marschall Manfred
Abstract excerpt
Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in immunocompromised individuals and neonates. The success of standard antiviral therapy is hampered by low drug compatibility and induction of viral resistance. A novel strategy is based on the exploitation of cell-directed signaling inhibitors. The broad antiinfective drug artesunate (ART) offers additional therapeutic...
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