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Article

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.

PloS one - 1 Jan 2015

Fusser Markus, Kernstock Stefan, Aileni Vinay Kumar, Egge-Jacobsen Wolfgang, Falnes Pål Ø, Klungland Arne

Abstract excerpt

Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT). Here, we generated and validated a constitutive knockout mouse by targeting exon 1-4 of the Vcpkmt gene. We show that Vcpkmt is ubiquitously expressed in all tissues examined and confirm the...

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Source

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Identifiers

PMID: 26544960
DOI: 10.1371/journal.pone.0141472
PMCID: PMC4636187

Genes

VCP
VCPKMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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