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Article

A clinicopathologic study of malignancy in VCP-associated multisystem proteinopathy.

Orphanet journal of rare diseases - 15 Jul 2022

Shmara Alyaa, Perez-Rosendahl Mari, Murphy Kady, Kwon Ashley, Smith Charles, Kimonis Virginia

Abstract excerpt

BACKGROUND: Valosin containing protein (VCP) is an important protein with many vital functions mostly related to the ubiquitin-proteasome system that provides protein quality control. VCP-associated inclusion body myopathy with Paget disease of bone and frontotemporal dementia, also termed VCP disease and multisystem proteinopathy (MSP 1), is an autosomal dominant disorder caused by monoallelic variants in...

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Source

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Identifiers

PMID: 35841038
DOI: 10.1186/s13023-022-02403-9
PMCID: PMC9287862

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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