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Article

Heritability of complex white matter diffusion traits assessed in a population isolate.

Human brain mapping - 1 Feb 2016

Kochunov Peter, Fu Mao, Nugent Katie, Wright Susan N, Du Xiaoming, Muellerklein Florian, Morrissey Mary, Eskandar George, Shukla Dinesh K, Jahanshad Neda, Thompson Paul M, Patel Binish, Postolache Teodor T, Strauss Kevin A, Shuldiner Alan R, Mitchell Braxton D, Hong L Elliot

Abstract excerpt

INTRODUCTION: Diffusion weighted imaging (DWI) methods can noninvasively ascertain cerebral microstructure by examining pattern and directions of water diffusion in the brain. We calculated heritability for DWI parameters in cerebral white (WM) and gray matter (GM) to study the genetic contribution to the diffusion signals across tissue boundaries. METHODS: Using Old Order Amish (OOA) population isolate with...

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Identifiers

PMID: 26538488
DOI: 10.1002/hbm.23047
PMCID: PMC4718876

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