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Article

Presence of nucleotide substitutions in the ABO promoter in individuals with phenotypes A3 and B3.

Vox sanguinis - 1 Apr 2016

Isa K, Yamamuro Y, Ogasawara K, Yabe R, Ogiyama Y, Ito S, Takahashi Y, Kominato Y, Sano R, Uchikawa M

Abstract excerpt

Recently, the involvement of mutation and deletion of transcription regulatory elements in the Bm , Am , A3 and B3 phenotypes has been reported. In the present study, we carried out genetic analysis of individuals with A3 and B3 using peptide nucleic acid-clamping PCR to exclude amplification of O alleles. Two single-point mutations, -76G>C and -68G>T, were found in the ABO promoter on the A-allele in three A3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26529276
DOI: 10.1111/vox.12363

Genes

ABO

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