Article
Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinical prognosis and chemotherapy responses of esophageal squamous cell carcinoma in China.
Oncotarget - 19 Jan 2016
Song Bin, Cui Heyang, Li Yaoping, Cheng Caixia, Yang Bin, Wang Fang, Kong Pengzhou, Li Hongyi, Zhang Ling, Jia Zhiwu, Bi Yanghui, Wang Jiaqian, Zhou Yong, Liu Jing, Wang Juan, Zhao Zhenxiang, Zhang Yanyan, Hu Xiaoling, Shi Ruyi, Yang Jie, Liu Haiyan, Yan Ting, Li Yike, Xu Enwei, Qian Yu, Xi Yanfeng, Guo Shiping, Chen Yunqing, Wang Jinfen, Li Guodong, Liang Jianfang, Jia Junmei, Chen Xing, Guo Jiansheng, Wang Tong, Zhang Yanbo, Li Qingshan, Wang Chuangui, Cheng Xiaolong, Zhan Qimin, Cui Yongping
Abstract excerpt
BACKGROUND: Recurrent genetic abnormalities that correlate with clinical features could be used to determine patients' prognosis, select treatments and predict responses to therapy. Esophageal squamous cell carcinoma (ESCC) contains genomic alterations of undefined clinical significance. We aimed to identify mutually exclusive mutations that are frequently detected in ESCCs and characterized their associations...
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