Article
[KRAS and bronchial adenocarcinoma. Between disappointments and hopes].
Revue des maladies respiratoires - 1 Feb 2016
Guibert N, Ilie M, Léna H, Didier A, Hofman P, Mazieres J
Abstract excerpt
A better understanding of oncogenesis and the development of targeted therapies have led to improved outcomes in the treatment of lung cancer. KRAS mutation has the potential to drive the oncogenesis of almost one third of lung adenocarcinomas but it leads to a highly complex proliferation signal involving multiple signaling pathways, explaining the disappointing results of various inhibition strategies of K-ras...
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