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Article

Disease tolerance mediated by microbiome <i>E. coli</i> involves inflammasome and IGF-1 signaling

29 Oct 2015

Abstract excerpt

Infections and inflammation can lead to cachexia and wasting of skeletal muscle and fat tissue by as yet poorly understood mechanisms. We observed that gut colonization of mice by a strain of Escherichia coli prevents wasting triggered by infections or physical damage to the intestine. During intestinal infection with the pathogen Salmonella Typhimurium or pneumonic infection with Burkholderia thailandensis, the...

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PMID: 26516283
DOI: 10.1126/science.aac6468

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