Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction.

Disease models & mechanisms - 1 Dec 2015

Chakraborty Mouli, Selma-Soriano Estela, Magny Emile, Couso Juan Pablo, Pérez-Alonso Manuel, Charlet-Berguerand Nicolas, Artero Ruben, Llamusi Beatriz

Abstract excerpt

Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by conduction defects and supraventricular and ventricular tachycardia, and carries a high risk of sudden cardiac death. Despite its importance, very few animal model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmias, Cardiac
Share to Diastole

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heart Rate

Share to Myocardial Contraction

Share to Myotonic Dystrophy

Share to Systole

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 26515653
DOI: 10.1242/dmm.021428
PMCID: PMC4728315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction.PMID 26515653Read ↗

Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 ModelsSemantic proximity Read ↗

MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model.Semantic proximity Read ↗

Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genesSemantic proximity Read ↗

Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophySemantic proximity Read ↗

<i>Straightjacket/α2δ3</i> deregulation is associated with cardiac conduction defects in Myotonic Dystrophy type 1Semantic proximity Read ↗

Furamidine Rescues Myotonic Dystrophy Type I Associated Mis-Splicing through Multiple MechanismsSemantic proximity Read ↗

Natural Compound Boldine Lessens Myotonic Dystrophy Type 1 Phenotypes in DM1 Drosophila Models, Patient-Derived Cell Lines, and HSALR Mice.Semantic proximity Read ↗

Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models.Semantic proximity Read ↗

Mice transgenic for the human myotonic dystrophy region with expanded CTG repeats display muscular and brain abnormalities.Semantic proximity Read ↗

Progressive cardiac phenotypes and reduced reversibility from long-term CUGexp RNA expression in a DM1 mouse model.Semantic proximity Read ↗

Systemic therapy in an RNA toxicity mouse model with an antisense oligonucleotide therapy targeting a non-CUG sequence within the DMPK 3′UTR RNASemantic proximity Read ↗

Optical Mapping Approaches on Muscleblind-Like Compound Knockout Mice for Understanding Mechanistic Insights Into Ventricular Arrhythmias in Myotonic Dystrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.