Article
Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.
Oncotarget - 8 Dec 2015
Li Xuesen, Yokoyama Noriko N, Zhang Saiyang, Ding Lina, Liu Hong-min, Lilly Michael B, Mercola Dan, Zi Xiaolin
Abstract excerpt
S phase kinase-associated protein 2 (Skp2) has been shown to be required for spontaneous tumor development that occurs in the retinoblastoma protein (pRb) deficient mice. Here we have demonstrated that flavokawain A (FKA), a novel chalcone from the kava plant, selectively inhibited the growth of pRb deficient cell lines and resulted in a proteasome-dependent and ubiquitination-mediated Skp2 degradation....
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