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Article

Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection.

Scientific reports - 20 Oct 2015

Hou Panpan, Chen Shuliang, Wang Shilei, Yu Xiao, Chen Yu, Jiang Meng, Zhuang Ke, Ho Wenzhe, Hou Wei, Huang Jian, Guo Deyin

Abstract excerpt

Genome editing via CRISPR/Cas9 has become an efficient and reliable way to make precise, targeted changes to the genome of living cells. CXCR4 is a co-receptor for the human immunodeficiency virus type 1 (HIV-1) infection and has been considered as an important therapeutic target for AIDS. CXCR4 mediates viral entry into human CD4(+) cells by binding to envelope protein, gp120. Here, we show that human CXCR4 gene...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26481100
DOI: 10.1038/srep15577
PMCID: PMC4612538

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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