Article
Characterisation of SEQ0694 (PrsA/PrtM) of Streptococcus equi as a functional peptidyl-prolyl isomerase affecting multiple secreted protein substrates.
Molecular bioSystems - 1 Dec 2015
Ikolo Felicia, Zhang Meng, Harrington Dean J, Robinson Carl, Waller Andrew S, Sutcliffe Iain C, Black Gary W
Abstract excerpt
Peptidyl-prolyl isomerase (PPIase) lipoproteins have been shown to influence the virulence of a number of Gram-positive bacterial human and animal pathogens, most likely through facilitating the folding of cell envelope and secreted virulence factors. Here, we used a proteomic approach to demonstrate that the Streptococcus equi PPIase SEQ0694 alters the production of multiple secreted proteins, including at least...
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