Article
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.
Blood - 15 Dec 2005
Taussig David C, Pearce Daniel J, Simpson Catherine, Rohatiner Ama Z, Lister T Andrew, Kelly Gavin, Luongo Jennifer L, Danet-Desnoyers Gwenn-Aël H, Bonnet Dominique
Abstract excerpt
Human hematopoietic stem cells (HSCs) are generally regarded as being devoid of the markers expressed by differentiated blood cells, the lineage-specific antigens. However, recent work suggests that genes associated with the myeloid lineage are transcribed in mouse HSCs. Here, we explore whether myeloid genes are actually translated in human HSCs. We show that CD33, CD13, and CD123, well-established myeloid...
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