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Article

Calreticulin mutation burden--is it a stable clone in patients with essential thrombocythemia and myelofibrosis?

Blood cells, molecules & diseases - 1 Dec 2015

Shuly Yulia, Nagar Meital, Ben-Asaf Lior, Kneller Abraham, Steinberg David M, Amariglio Ninette, Salomon Ophira

Abstract excerpt

Calreticulin mutation represents the second most frequent mutation after JAK2 V617F in myeloproliferative disorder and is considered to be a driving mutation. Herein the mutation burden was evaluated in patients with essential thrombocythemia or myelofibrosis and found to increase by 5.7% over time unrelated to the time elapsed from the initial to the final positive test. The longer the course of the disease when...

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Source

Identifiers

PMID: 26460248
DOI: 10.1016/j.bcmd.2015.07.011

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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