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YXL-13 attenuates virulence in Pseudomonas aeruginosa mutants and clinical isolates by inhibiting quorum sensing regulators LasR and RhlR.

Microbial pathogenesis - 1 Mar 2026

Wang Lei, Luo Rui, Yan Xinlin, Han Mengliang, Zhang Mingjie, Xiao Junhai, Zhao Kelei, Lin Feng

Abstract excerpt

Given the critical role of quorum sensing (QS) in the pathogenicity of Pseudomonas aeruginosa, inhibiting QS is considered a promising alternative to traditional antibiotics for treating P. aeruginosa infections. The QS system of P. aeruginosa comprises two acyl-homoserine lactone (AHL) circuits, LasI/R and RhlI/R, along with a third system, the PQS system. However, due to the frequent clinical isolation of lasR...

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PMID: 41520905
DOI: 10.1016/j.micpath.2026.108298

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