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Article

The cataract-associated V41M mutant of human γS-crystallin shows specific structural changes that directly enhance local surface hydrophobicity.

Biochemical and biophysical research communications - 3 Jan 2014

Bharat Somireddy Venkata, Shekhtman Alexander, Pande Jayanti

Abstract excerpt

The major crystallins expressed in the human lens are γS-, γC- and γD-crystallins. Several mutations in γS-crystallin are associated with hereditary cataracts, one of which involves the substitution of a highly conserved Valine at position 41 to Methionine. According to a recent report, the mutant protein, V41M, shows lower stability and increased surface hydrophobicity compared to the wild-type, and a propensity...

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Identifiers

PMID: 24287181
DOI: 10.1016/j.bbrc.2013.11.073
PMCID: PMC3927989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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