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Variations in the Processing of DNA Double-Strand Breaks Along 60-MeV Therapeutic Proton Beams

30 Jul 2015

Abstract excerpt

PURPOSE: To investigate the variations in induction and repair of DNA damage along the proton path, after a previous report on the increasing biological effectiveness along clinically modulated 60-MeV proton beams. METHODS AND MATERIALS: Human skin fibroblast (AG01522) cells were irradiated along a monoenergetic and a modulated spread-out Bragg peak (SOBP) proton beam used for treating ocular melanoma at the...

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PMID: 26452569
DOI: 10.1016/j.ijrobp.2015.07.2279

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