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Article

Differential gene expression in primary fibroblasts induced by proton and cobalt-60 beam irradiation

8 Sept 2017

Abstract excerpt

INTRODUCTION: Proton beam therapy delivers a more conformal dose distribution than conventional radiotherapy, thus improving normal tissue sparring. Increasing linear energy transfer (LET) along the proton track increases the relative biological effectiveness (RBE) near the distal edge of the Spread-out Bragg peak (SOBP). The severity of normal tissue side effects following photon beam radiotherapy vary...

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PMID: 28885067
DOI: 10.1080/0284186x.2017.1351623

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