Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer.

doi:10.1158/1078-0432.CCR-15-0256

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Article

Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2016

Hurley Paula J, Sundi Debasish, Shinder Brian, Simons Brian W, Hughes Robert M, Miller Rebecca M, Benzon Benjamin, Faraj Sheila F, Netto George J, Vergara Ismael A, Erho Nicholas, Davicioni Elai, Karnes R Jeffrey, Yan Guifang, Ewing Charles, Isaacs Sarah D, Berman David M, Rider Jennifer R, Jordahl Kristina M, Mucci Lorelei A, Huang Jessie, An Steven S, Park Ben H, Isaacs William B, Marchionni Luigi, Ross Ashley E, Schaeffer Edward M

Abstract excerpt

PURPOSE: Prostate cancers incite tremendous morbidity upon metastatic growth. We previously identified Asporin (ASPN) as a potential mediator of metastatic progression found within the tumor microenvironment. ASPN contains an aspartic acid (D)-repeat domain and germline polymorphisms in D-repeat-length have been associated with degenerative diseases. Associations of germline ASPN D polymorphisms with risk of...

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PMID: 26446945
DOI: 10.1158/1078-0432.CCR-15-0256
PMCID: PMC4715968

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ASPN

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