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Article

Substrate Availability of Mutant SPT Alters Neuronal Branching and Growth Cone Dynamics in Dorsal Root Ganglia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Oct 2015

Jun Byung Kyu, Chandra Ankush, Kuljis Dika, Schmidt Brian P, Eichler Florian S

Abstract excerpt

Serine palmitoyltransferase (SPT) is a key enzyme in the first step of sphingolipid biosynthesis. Mutations in the SPTLC1 gene that encodes for SPT subunits cause hereditary sensory neuropathy type 1. However, little is understood about how mutant SPT regulates mechanisms of sensory neuron and axonal growth. Using transgenic mice overexpressing the C133W SPT mutant, we found that mutant dorsal root ganglia (DRG)...

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Identifiers

PMID: 26446223
DOI: 10.1523/JNEUROSCI.1403-15.2015
PMCID: PMC4595622

Genes

SPTLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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