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Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia

6 Oct 2015

Abstract excerpt

BACKGROUND: Specific genes, such as BCAT1 and IKZF1, are methylated with high frequency in colorectal cancer (CRC) tissue compared to normal colon tissue specimens. Such DNA may leak into blood and be present as cell-free circulating DNA. We have evaluated the accuracy of a novel blood test for these two markers across the spectrum of benign and neoplastic conditions encountered in the colon and rectum. METHODS:...

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PMID: 26445409
DOI: 10.1186/s12885-015-1674-2

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