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Bacteriophages engineered to display foreign peptides may become short‐circulating phages

29 Apr 2019

Abstract excerpt

Bacteriophages draw scientific attention in medicine and biotechnology, including phage engineering, widely used to shape biological properties of bacteriophages. We developed engineered T4-derived bacteriophages presenting seven types of tissue-homing peptides. We evaluated phage accumulation in targeted tissues, spleen, liver and phage circulation in blood (in mice). Contrary to expectations, accumulation of...

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PMID: 31037835
DOI: 10.1111/1751-7915.13414

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