Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial Transfer of the Mutant Human <i>ND6T14484C</i> Gene Causes Visual Loss and Optic Neuropathy

1 Oct 2020

Abstract excerpt

Purpose: To evaluate the long-term effects of mitochondrial gene transfer of mutant human NADH ubiquinone oxidoreductase subunit VI (hND6T14484C) in the mouse eye. Methods: Adult mice were injected intravitreally with mitochondrial-targeted adeno-associated virus carrying either hND6T14484C or mitochondrial encoded mCherry. The delivery and expression of the interest gene were detected by polymerase chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Mitochondrial Function and Pathology
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33101779
DOI: 10.1167/tvst.9.11.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial Transfer of the Mutant Human <i>ND6T14484C</i> Gene Causes Visual Loss and Optic NeuropathyPMID 33101779Read ↗

Mitochondrially Targeted Gene Therapy Rescues Visual Loss in a Mouse Model of Leber’s Hereditary Optic NeuropathySemantic proximity Read ↗

Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.Semantic proximity Read ↗

Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation.Semantic proximity Read ↗

Leber Hereditary Optic Neuropathy Gene Therapy Clinical Trial RecruitmentSemantic proximity Read ↗

Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.Semantic proximity Read ↗

Longterm Reversal of Severe Visual Loss by Mitochondrial Gene Transfer in a Mouse Model of Leber Hereditary Optic Neuropathy.Semantic proximity Read ↗

The pathological mechanisms and novel therapeutics for Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction.Semantic proximity Read ↗

Developments in the Treatment of Leber Hereditary Optic Neuropathy.Semantic proximity Read ↗

Generation of a human iPSC line, FINCBi001-A, carrying a homoplasmic m.G3460A mutation in MT-ND1 associated with Leber's Hereditary optic Neuropathy (LHON).Semantic proximity Read ↗

Vitamin A treatment restores vision failures arising from Leber's hereditary optic neuropathy-linked mtDNA mutation.Semantic proximity Read ↗

Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.