Article
Treatment with a novel oleic-acid-dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats.
Disease models & mechanisms - 1 Oct 2015
Decara Juan M, Pavón Francisco Javier, Suárez Juan, Romero-Cuevas Miguel, Baixeras Elena, Vázquez Mariam, Rivera Patricia, Gavito Ana L, Almeida Bruno, Joglar Jesús, de la Torre Rafael, Rodríguez de Fonseca Fernando, Serrano Antonia
Abstract excerpt
Fatty liver disease is one of the main hepatic complications associated with obesity. To date, there are no effective treatments for this pathology apart from the use of classical fibrates. In this study, we have characterized the in vivo effects of a novel conjugation of oleic acid with an amphetamine derivative (OLHHA) in an animal model of genetic obesity. Lean and obese Zucker rats received a daily...
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